Preliminary program

Program

Day 1 - Thursday February 2nd

8h30-8h45. Welcome to participants in the IRCM hall.

8h45-9h00. Welcome talk. Thierry Lavabre Bertrand (Vice-president of the University of Montpellier)

et Nathalie Bonnefoy (IRCM Director)

9h00-9h15. Presentation of the MAD4Cancer ERASMUS Master project. Natalia Pellegata (Pavia

University (Master coordinator) & Marie-Alix Poul (University of Montpellier).

Session 1.

Chaired by Natalia Pellegata and Guillaume Serwe

9:15-9h45. Rossella Tricarico (University of Pavia). Epigenetic control by active DNA demethylation in

colorectal cancer tumorigenesis

9:45-10:05. Caroline Labelle (IRIC). Enhancing the drug discovery process: Selecting relevant and

potent compounds with Bayesian inference.

10:05-10:25. Fatima Alhourani (E Julien's team, IRCM). Targeting SUV4-20h enzymes as epigenetic strategy for prostate cancer treatment.

10:25-11:00. COFFEE BREAK

Session 2.

Chaired by Marie-Alix Poul and Dana Naim

11:00-11:30. Julie Lessard (IRIC). Role of SWI/SNF chromatin remodeling complexes in normal and leukemic hemopoiesis.

11:30-11:50. Federica Gentile (University of Pavia). Experimental and bioinformatic approaches to identify novel tumorigenic pathways.

11:50-12:20. Jacques Colinge (IRCM). Inferring the cellular networks of tumors.

12:20:14:00. LUNCH BREAK.

Session 3

Chaired by Sébastien Carreno and Airelle Lahalle

14:00-14:30. Daniel Fisher (IGMM). Towards Adaptive Therapy with kinase inhibitors.

14:30-14:50. Chloé Tesnière (IRIC). The pH as a new regulator for the stability of the atypical MAPK ERK3

and its potential implication for breast cancer progression.

14:50-15:10. Dana Naim (S Roche's team, CRBM). Deciphering SRC-Like Adaptor Protein (SLAP) functions

in intestinal homeostasis and tumorigenesis

15:10-15:30. Alessia Foscarini (University of Pavia). Functional characterization of Tribbles pseudokinases

in gastric cancer.

15:30-16:05. COFFEE BREAK

Session 4

Chaired by Stéphane Bodin and Alessia Foscarini

16:05-16:35. Domenico Maiorano (IGH). Studying the DNA damage response in embryos and its relevance to cancer.

16:35-16:55. Guillaume Serwe (IRIC). The scaffold protein CNK2 drives cell migration, invasion, and metastasis

in cancer cells.

16:55-17:25. Vincent Trinh (IRIC). Fibroblasts and stellate cells in the tumor microenvironment of pancreatic cancer precursor cells.

Day 2 - February February 3rd

Session 5

Chaired by Vincent Trinh and Fatima Alhourani

9:00-9:30. Natalia Pellegata (University of Pavia). A functional angiopoietin-2/Tie-2 autocrine loop as

novel therapeutic target in pituitary neuroendocrine tumors.

9:30-10:00. Andre Turtoi (IRCM). What can we learn from spatial transcriptomics in human solid cancer.

10:00-10:20. Gabriel Alzial (IRIC). Metabolic adaptations contribute to changes in cell identity through

epigenetic reprogramming in triple-negative breast cancer.

10:20-10h55. COFFEE BREAK

Session 6

Chaired by Jérôme Moreaux and Marine Bernardet

10:55-11:25. Pierre Thibault (IRIC). Immunopeptidome dark matter reveals unsuspected source of tumor

specific antigens

11:25-11:55. Dimitris Xirodimas (CRBM). Targeting the Ubiquitin/Ubiquitin-like system in cancer.

11:55-12:15 Airelle Lahalle (L Le Cam's team, IRCM). The p53 pathway and lipid metabolism: implications in liver function and HCC development.

12:15:14:00. LUNCH BREAK.

Session 7

Chaired by Julie Lessard and Caroline Labelle.

14:00-14:30. Julie Constanzo (IRCM). Role of cell membrane in bystander cytoxicity and immunity of

targeted radionucleide therapy.

14:30-15:00. Jérôme Moreaux (IGH). Targeting cellular iron homeostasis in B cell malignancies.

15:00-15:20. Zeinab Homayed (J Pannequin's team IGF). Early dissemination in colorectal cancer.

15:20-15:40. Marine Bernardet (D Grégoire group, IGMM). In vivo Analysis reveals content-specific gain of fonction phenotype of p53 in hepatocellular carcinoma.

15:40-16:15. COFFEE BREAK

Session 8

Chaired by Natalia Pellegata and Gabriel Alzial

16:15-16:45. Sébastien Carreno (IRIC). The G protein-coupled receptor TBXA2R activates ERMs to potentiate motility, invasion, and metastasis of triple-negative breast cancer cells.

16:45-17:15. Stéphane Bodin (CRBM). Overexpression of flotillins in cancers derails endosomal trafficking and promotes cell invasion.

17:15-18:00. End of the symposium. Discussion and concluding remarks on how to foster international collaboration between our institutes ?